Pharma Ampoule Filling Machine

Pharma Ampoule Filling Machine

Description:

A Pharma Ampoule Filling Machine** is an advanced pharmaceutical equipment used for filling sterile liquid formulations into glass ampoules under aseptic conditions. It performs multiple tasks such as washing, filling, pre/post-gas flushing, and sealing, ensuring precise dosing and zero contamination.

This machine is critical in injectable drug manufacturing, offering high-speed, accurate, and GMP-compliant filling for small volume parenterals (SVPs).

How It’s Made:

Body Structure & Material:
- Constructed with SS 304/316L grade stainless steel for hygienic and corrosion-resistant build.
- Polished and enclosed to comply with cGMP and cleanroom norms.
Feeding & Transport Mechanism:
- Ampoules are transported using slotted conveyor or slat belt to the filling station.
- Ampoule holders and indexing turret ensure stable movement.
Washing & Sterilization Unit (Optional):
- Inline ampoule washing system with internal/external washing jets using purified water & compressed air.
Filling System:
- Uses volumetric piston pumps, peristaltic pumps, or syringes for accurate dosing (0.5ml to 20ml+).
- Dosing precision: ±1–2%.
Gas Purging & Sealing:
- Nitrogen flushing system (before & after filling) to reduce oxidation.
- Flame sealing station using LPG and oxygen burners.
Automation & Control:
- Fully or semi-automatic machines with PLC control, touchscreen HMI, auto shutdown, and error alerts.

Where It’s Used:

Pharmaceutical Injectable Plants
Hospitals & Research Labs (for small-scale production)
Biotech & Vaccine Manufacturing Units
Diagnostic Reagent Bottling
Contract Manufacturing & Third-Party Pharma Units
Veterinary Drug Manufacturers

Key Features:

Dosing Range: 0.5 ml to 30 ml
Output Speed: 60–250 ampoules/min (model dependent)
Supports Ampoule Sizes: 1ml to 20ml (Open/Closed Mouth)
100% Contactless Operation in Sterile Environments
Digital Controls for Dose Adjustment
Integrated Flame Sealing Mechanism
Easy-To-Clean, GMP-Compliant Construction
Inbuilt Sensors for No-Ampoule-No-Fill Safety

Importance:

Ampoule filling machines are essential for safe drug delivery, especially injectable and intravenous (IV) medications. They ensure sterility, dosage accuracy, and production efficiency, meeting international pharmaceutical standards.

Advantages:

High Fill Accuracy with Minimal Wastage
Ideal for Small and Large Volume Sterile Liquids
Meets WHO, GMP, and USFDA Guidelines
Reduced Downtime with Auto-Lubrication & Alerts
Customizable for Different Ampoule Sizes and Doses
Modular Design – Easy Integration with Washing & Labelling Machines
Ideal for Domestic and Export-Oriented Production

Significance:

In the global pharmaceutical ecosystem, injectable drugs are high-risk and high-value. Ampoule filling machines make the process safe, sterile, and scalable, reducing manual handling, ensuring compliance, and helping brands maintain quality integrity across markets.

Indicative Price Range in India:

Model Type	Output (amp/min)	Price (INR)
Semi-Automatic (2 head)	30 – 60	₹4.5 – ₹6.5 Lakhs
Automatic (4 head)	90 – 120	₹8 – ₹12 Lakhs
High-Speed (6-8 head)	150 – 250	₹15 – ₹25 Lakhs+

FAQs:

Q1. Can this machine handle different ampoule sizes?
A: Yes, with interchangeable change parts, it supports 1ml to 20ml open or closed mouth ampoules.

Q2. Is nitrogen purging optional?
A: Yes, pre/post-nitrogen purging can be added for oxygen-sensitive formulations.

Q3. Is the machine suitable for vaccine filling?
A: Absolutely. Fully automatic versions with HEPA-filter enclosures meet aseptic filling standards for vaccines.

Q4. What kind of maintenance does it need?
A: Minimal. Basic lubrication and filter checks. SS parts are easy to clean and sterilize.

Q5. Can it be connected with other machines?
A: Yes. It can be integrated with ampoule washing, drying, labeling, and packing machines for a complete line.

Conclusion:

A Pharma Ampoule Filling Machine is a critical component in sterile liquid drug production. It offers unmatched dose accuracy, speed, sterility, and regulatory compliance. Whether you’re a small injectable unit or a large-scale manufacturer, this machine delivers trusted performance with a quick ROI. India’s growing pharmaceutical infrastructure depends on such efficient, locally manufactured machinery for both domestic use and global supply chains.

Contact:-+91 9825099693

Gmail:-info@harsiddh.in

Website:-https://www.harsiddhmachines.com/

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Pharma Ampoule Filling Machine