Automatic Four-Head Ampoule Filling & Sealing Machine
High-Throughput, Sterile Liquid Processing for Medium to Large-Scale Pharmaceutical Operations
In the stringent world of sterile injectable manufacturing, absolute sterility, micro-precision dosing, and consistent throughput are non-negotiable. The Harsiddh Automatic Four-Head Ampoule Filling & Sealing Machine stands at the forefront of parenteral processing technology.
Meticulously engineered for medium-to-large pharmaceutical facilities, biotech laboratories, and contract manufacturers (CMOs), this industrial-grade, cGMP-compliant system automates the delicate process of filling and hermetically sealing glass ampoules—delivering high-efficiency output within a optimized cleanroom footprint. Featuring a synchronized four-head architecture, it processes four ampoules simultaneously per cycle, managing pre-gassing, exact filling, and uniform flame sealing flawlessly.
Strategic Benefits & ROI Highlights
- High-Speed, Synchronized Output: Achieves scalable filling rates of 60 to 90 ampoules per minute via an integrated Variable Frequency Drive (VFD).
- Zero Fluid Waste: Intelligent “No Ampoule – No Filling” optical sensors automatically deactivate individual nozzles if a gap is detected, preventing costly product spillage.
- Frictionless Handling: Combines a Slant Travel Principle with a Rectangle Feeding System to eliminate glass-on-glass shocks, virtually eliminating ampoule breakage or tipping at high speeds.
- Rapid Batch Changeovers: Tool-less, modular change parts allow operators to transition between different ampoule capacities (1ml to 5ml) within minutes, maximizing your line’s Overall Equipment Effectiveness (OEE).
- LAF-Ready Architecture: Clean, open-table design allows unobstructed laminar airflow (LAF) to pass through the filling zone, maintaining Class A sterility boundaries.
The 5-Step Automated Processing Cycle
From the moment empty, sterilized ampoules enter the feed hopper, the machine executes a highly coordinated, continuous sequence:
[Infeed Hopper] ➔ [1. Pre-N₂ Flushing] ➔ [2. Micro-Precision Fill] ➔ [3. Post-N₂ Flushing] ➔ [4. Rotary Pre-Heating & Flame Seal] ➔ [5. Outfeed Guide]- Pre-Nitrogen Flushing: Drives out atmospheric oxygen from empty ampoules to protect oxidation-sensitive liquid formulations.
- Precision Liquid Filling: Four volumetric or positive-displacement syringes descend smoothly into the ampoule necks to dispense exact liquid volumes simultaneously, minimizing expensive product giveaway.
- Post-Nitrogen Flushing: Displaces oxygen remaining in the headspace directly above the liquid layer, expanding shelf-life.
- Pre-Heating & Neck Sealing: Specialized gas burners apply concentrated, uniform heat to the ampoule necks while the containers gently rotate, creating a perfect, hermetic dome seal.
- Automated Discharge: Sealed containers are smoothly guided onto the outfeed collection tray, pristine and ready for downstream optical inspection or serialization.
Advanced Materials & Premium Engineering
Surgical-Grade AISI 316L Contact Zones
Every component directly touching your liquid formulation—including the filling needles, dosing syringes, delivery lines, and manifolds—is fabricated from Stainless Steel AISI 316L. This premium composition provides absolute resistance to chemical corrosion, pitting, and degradation, ensuring formulation purity.
Heavy-Duty AISI 304 Chassis
The structural frame, outer cladding, and safety enclosures are built from Stainless Steel AISI 304. The smooth, matte-finished surfaces repel cleanroom dust, resist aggressive sanitizing agents, and allow for effortless, rapid wipe-down sanitization.
Bespoke Customization & 21 CFR Part 11 Readiness
We custom-build machinery to fit your exact facility blueprint. Available engineering upgrades include:
- Advanced PLC control integration with multi-lingual Touchscreen HMIs.
- Secure data-logging and audit trail software configuration for 21 CFR Part 11 compliance.
- Custom-profiled positive displacement pumps optimized for high-viscosity or volatile fluids.
Technical Specification
| Model No. | HFS-4 / Off Line model |
| Ampoule Sizes | 1ml to 5ml Open Mouth Glass Ampoules |
| Filling Capacity | From 0.5ml to 5ml in single dose |
| Filling Type | Piston Pumps Type Filling (Volumetric) |
| Contact Parts | Stainless Steel AISI 316L (For Filling Nozzle & Syringe / Pump) |
| Output / Minute | 60 to 90 Ampoules / Minute (Depend on ampoules sizes) |
| No. of Head For Fill & Seal | Four |
| Require Gases For Sealing | LPG & Oxygen (Mixture) |
| Nitrogen Purging | Available (Pre & Post) |
| Pre Heating | Available |
| Power Require | 1 H.P., 380 Volts, 3 Phase, 50 Hz (4 Wire Systems) OR 1 H.P., 220 Volts, 1 Phase, 50 Hz OR Customised |
| Over All Dimensions | 1050mm (L) X 800mm (W) X 1000mm (H) |
| Net Weight | 285 Kgs. |
| Gross Weight (With Wooden Case) | 460 Kgs. |
Why Choose Harsiddh Unimach?
Harsiddh Unimach is globally recognized for manufacturing high-caliber, reliable pharmaceutical packaging machinery. Our commitment to using premium metallurgy, precision electronics, and user-centric mechanical designs guarantees that your capital investment will deliver consistent performance for decades.
By combining low-maintenance mechanical drives with highly responsive safety interlocks, we ensure that your operations run smoothly with minimal technical intervention. Elevate your production quality, safeguard your liquid formulations, and scale your manufacturing output with the Automatic Four-Head Ampoule Filling & Sealing Machine.
Contact our technical sales team today to request a customized quote, review detailed engineering drawings, or schedule a live video demonstration.
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