Automatic Eight Head Ampoule Filling Sealing Machine

Automatic Eight Head Ampoule Filling & Sealing Machine

Maximize Throughput without Compromising Sterility

In high-volume pharmaceutical manufacturing, speed is meaningless without absolute precision and sterility. The Harsiddh Automatic Eight Head Ampoule Filling & Sealing Machine stands as an industry-leading, flagship solution designed specifically for high-capacity parenteral production lines.

Engineered to endure continuous, heavy-duty operational demands, this robust system seamlessly integrates advanced mechanical synchronization with modern automation. Built around the internationally proven Angle Travel Principle, it delivers flawless volumetric dosing and airtight, hermetic sealing for glass ampoules—ensuring total compliance with stringent cGMP guidelines.

Key Benefits for Pharma Manufacturers

• Unparalleled Production Speeds: Deliver between 80 to 225 perfectly sealed units per minute to keep large-scale manufacturing batches moving efficiently.
• Dynamic Multi-Volume Versatility: Effortlessly transition between 1ml, 2ml, 3ml, 5ml, and 10ml open-mouth glass ampoules with minimal changeover parts.
• Contamination-Free Architecture: Constructed using premium-grade stainless steel with a hands-free layout, significantly lowering the risk of human-borne batch contamination.
• Ultra-Precise Dosing Accuracy: Advanced volumetric piston pumps eliminate expensive product giveaway and guarantee strict uniformity of content across all batches.

Step-by-Step Operational Process

The system utilizes a completely automated, synchronized master-cam mechanism that guarantees a gentle, vibration-free journey for delicate glass containers, eliminating breakage and product loss.

1. Infeed and Sorting

Sterilized glass ampoules are loaded onto an integrated, inclined slant hopper. A synchronized star wheel or cassette magazine safely aligns the ampoules into a perfect vertical position for index-based movement.

2. Pre-Gassing Phase

To safeguard oxygen-sensitive formulations against oxidation and degradation, ampoules undergo immediate pre-nitrogen flushing to displace ambient atmospheric air with an inert gas shroud.

3. Precision Multi-Head Dosing

The eight-head nozzle assembly descends simultaneously into the ampoules. Utilizing highly accurate volumetric piston pumps, the liquid is discharged uniformly. A built-in “No-Ampoule, No-Fill” sensor array automatically halts dosing if a slot is vacant, preventing product waste.

4. Post-Gassing & Pre-Heating

Immediately after filling, a post-nitrogen purging cycle locks in the inert environment. The ampoules then glide into a specialized pre-heating zone, where glass tips are progressively heated to prevent structural shocking or thermal fracturing.

5. Hermetic Fuse Sealing

The heated ampoule tips move directly to the primary sealing station. Using a precisely calibrated mixture of LPG and Oxygen, the open-mouth tips are melted down and drawn off neatly, leaving a smooth, hermetically sealed finish free of cosmetic defects or pinholes.

6. Automatic Discharge

Sealed ampoules are smoothly guided away from the hot zone and discharged into a structured vertical tray collection unit, instantly ready for optical inspection and secondary cartoning.

Advanced Engineering & Technical Architecture

Single-Motor Synchronization

A defining technical edge of this system is its centralized drive setup. All critical processing stages—from infeed star wheels to filling pumps and discharge units—are driven by a single, high-torque main motor. This completely eliminates timing drift across stations, ensuring flawless mechanical harmony even at peak processing speeds.

Variable Speed Control via Delta VFD

Production requirements change based on liquid viscosity, container size, and line staffing. The machine is outfitted with a cutting-edge Delta Variable Frequency Drive (VFD), giving operators the power to scale production speeds smoothly up or down without mechanical jerks, preserving the longevity of the drivetrain.

Ergonomic Hygiene & Washdown Design

Sterile environments require meticulous maintenance. The structural frame features a spacious layout with large open channels at the base. This smart design facilitates rapid washdowns, prevents liquid or glass debris accumulation, and provides maintenance engineers with unobstructed access to internal sub-assemblies.

High-Tech Customizable Upgrades

Future-proof your investment with Harsiddh’s suite of modular, high-tech upgrades designed for highly sensitive or specialized biochemical formulations:

• PLC Touch Screen HMI: Upgrade to a smart PLC controller (Siemens or Allen-Bradley) featuring a vibrant touchscreen interface. Enables digital recipe storage, real-time batch logging, diagnostic alerts, and full 21 CFR Part 11 compliance tracking.
• Servo-Driven Filling Systems: Replace standard mechanical linkages with precision servo motors. This allows operators to adjust filling volumes digitally via the interface screen in seconds, eliminating manual mechanical calibrations.
• Peristaltic Pump Integration: When dealing with shear-sensitive biopharmaceuticals, high-value proteins, or highly corrosive liquids, the machine can be configured with advanced peristaltic pump systems, ensuring the product only contacts medical-grade disposable tubing.

Technical Specification

Model No.	HFS-8 (High Speed)
Number of Heads	Eight (Filling & Sealing)
Production Output	80 to 225 Ampoules / Minute
Ampoule Size Range	1ml to 10ml Open Mouth
Filling Capacity	0.5ml to 10ml in Single Dose
Gases Required	LPG & Oxygen (for Sealing)
Power Requirements	1.5 H.P., 380V/220V Options
Machine Dimensions	2430mm (L) x 1200mm (W) x 1000mm (H)
Net Weight	Approx. 1270 Kgs

Partner with Harsiddh for Elite Liquid Fill-Seal Packaging

Choosing the Harsiddh Automatic Eight Head Ampoule Filling & Sealing Machine means choosing uncompromised reliability, continuous high-velocity output, and world-class engineering support. Whether you are scaling up an existing injectable line or introducing a new sterile liquid product to the market, the HFS-8 delivers the precision, safety, and efficiency required to keep your business ahead of the competition.

Contact our technical sales team today to discuss your specific filling volume requirements, request a custom quote, or schedule a virtual live demonstration. Let us help you elevate your pharmaceutical production capabilities to the next level.